Norepinephrine and Serotonin Metabolism and Clinical Response to Combined Imipramine and Amitriptyline Therapy in Depression
نویسندگان
چکیده
The present study was aimed to find out the alteration of NE and 5HT systems in depression, if so in the same direction or not and to find out the clinical response to combined therapy of Imipramine and Amitriptyline, both tricyclic antidepressants. The study group consisted of 39 depressives as defined by I. C. D. 9 and 17 normal controls. Hamilton Depression Rating Scale was used to assess the severity of depression initially and after clinical improvement with drugs. Urinary MHPG and CSF 5HIAA were estimated final] depressives as per the standard procedure. It was found that both urinary MHPG and CSF 5HIAA were lowered in depressives but when individual patients were analysed both were not altered in the same direction in a given individual. All the depressives showed equal therapautic response to combined administration of Imipramine and Amitripiyline.
منابع مشابه
Dexamethasone suppression test and selection of antidepressant medications.
Endogenous depressives with abnormal dexamethasone suppression tests (DSTs) respond better to somatic antidepressant treatments than those with normal DSTs. Whether the DST also aids in the selection of specific antidepressants has not been determined. A pilot report suggested that patients with abnormal DSTs might be noradrenaline-deficient and respond preferentially to imipramine or desiprami...
متن کاملEffect of Different Drugs Influencing Monoamine Neurotransmission on Haloperidol-Induced Catalepsy in Mice
Results: Catalepsy duration was reduced by the non-selective noradrenaline and serotonin reuptake inhibitors imipramine and amitriptyline (21.1% and 22.3% reduction by 20 mg/kg imipramine and amitriptyline, respectively). Catalepsy duration was increased by the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine, and citalopram and by the serotonin receptor antagonist and re...
متن کاملTranylcypromine in mind (Part I): Review of pharmacology
It has been over 50 years since a review has focused exclusively on the monoamine oxidase (MAO) inhibitor tranylcypromine (TCP). A new review has therefore been conducted for TCP in two parts which are written to be read preferably in close conjunction: Part I - pharmacodynamics, pharmacokinetics, drug interactions, toxicology; and Part II - clinical studies with meta-analysis of controlled stu...
متن کاملPharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants.
Selective agonists of the sigma-1 (σ(1)) ligand-operated chaperone protein, like igmesine or PRE-084, are antidepressants in preclinical depression models. σ(1)-Protein activation may contribute to the antidepressant efficacy of drugs known to act as selective serotonin-reuptake inhibitors (SSRI) or noradrenaline reuptake inhibitors through direct or indirect involvement of the σ(1)-receptor in...
متن کاملNontricyclic antidepressant analgesics and pain: are serotonin norepinephrine reuptake inhibitors (SNRIs) any better?
Almost 50 years of clinical investigation has resulted in a large amount of literature regarding pain and antidepressants, one of the first categories of drugs found effective for chronic noncancer pain (CNCP) by randomized controlled trials (RCTs). These RCTs first examined tricyclic antidepressants (TCAs) based on published observational data and the rationale that their actions potentiated d...
متن کامل